منابع مشابه
Human Neutrophils Kill Bacillus anthracis
Bacillus anthracis spores cause natural infections and are used as biological weapons. Inhalation infection with B. anthracis, the etiological agent of anthrax, is almost always lethal, yet cutaneous infections usually remain localized and resolve spontaneously. Neutrophils are typically recruited to cutaneous but seldom to other forms of anthrax infections, raising the possibility that neutrop...
متن کاملMurine macrophages kill the vegetative form of Bacillus anthracis.
Anti-protective antigen antibody was reported to enhance macrophage killing of ingested Bacillus anthracis spores, but it was unclear whether the antibody-mediated macrophage killing mechanism was directed against the spore itself or the vegetative form emerging from the ingested and germinating spore. To address this question, we compared the killing of germination-proficient (gp) and germinat...
متن کاملInnate Immune Interactions between Bacillus anthracis and Host Neutrophils
Bacillus anthracis, the causative agent of anthrax, has been a focus of study in host-pathogen dynamics since the nineteenth century. While the interaction between anthrax and host macrophages has been extensively modeled, comparatively little is known about the effect of anthrax on the immune function of neutrophils, a key frontline effector of innate immune defense. Here we showed that deplet...
متن کاملIn vitro susceptibility of Bacillus anthracis to various antibacterial agents and their time-kill activity.
OBJECTIVES To investigate the in vitro acquisition of resistance to antibiotics by Bacillus anthracis. METHODS The in vitro activities of 18 antibacterial agents against two strains of B. anthracis, the Sterne strain and the Russian anthrax vaccine strain ST-1, were tested by determining the MICs and by measuring the rates of antibiotic kill at 5x and 10x MIC. RESULTS The fluoroquinolones c...
متن کاملRetrocyclins kill bacilli and germinating spores of Bacillus anthracis and inactivate anthrax lethal toxin.
Theta-defensins are cyclic octadecapeptides encoded by the modified alpha-defensin genes of certain nonhuman primates. The recent demonstration that human alpha-defensins could prevent deleterious effects of anthrax lethal toxin in vitro and in vivo led us to examine the effects of theta-defensins on Bacillus anthracis (Sterne). We tested rhesus theta-defensins 1-3, retrocyclins 1-3, and severa...
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ژورنال
عنوان ژورنال: PLoS Pathogens
سال: 2005
ISSN: 1553-7374
DOI: 10.1371/journal.ppat.0010023